Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin

Recent cryo-EM structures show the highly dynamic nature of the MLL1-NCP (nucleosome core particle) interaction. Functional implication and regulation of such dynamics remain unclear. Here we show that DPY30 and the intrinsically disordered regions (IDRs) of ASH2L work together in restricting the ro...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Lee, Young-Tae, Ayoub, Alex, Park, Sang-Ho, Sha, Liang, Xu, Jing, Mao, Fengbiao, Zheng, Wei, Zhang, Yang, Cho, Uhn-Soo, Dou, Yali
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134635/
https://ncbi.nlm.nih.gov/pubmed/34012049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23268-9
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