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Decreased vascular smooth muscle contractility in Hutchinson–Gilford Progeria Syndrome linked to defective smooth muscle myosin heavy chain expression

Children with Hutchinson–Gilford Progeria Syndrome (HGPS) suffer from multiple cardiovascular pathologies due to the expression of progerin, a mutant form of the nuclear envelope protein Lamin A. Progerin expression has a dramatic effect on arterial smooth muscle cells (SMCs) and results in decrease...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: von Kleeck, Ryan, Castagnino, Paola, Roberts, Emilia, Talwar, Shefali, Ferrari, Giovanni, Assoian, Richard K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134495/
https://ncbi.nlm.nih.gov/pubmed/34012019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90119-4
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