Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase

Arterial stiffening and cardiac dysfunction are hallmarks of premature aging in Hutchinson–Gilford Progeria Syndrome (HGPS), but the molecular regulators remain unknown. Here, we show that the LaminA(G609G) mouse model of HGPS recapitulates the premature arterial stiffening and early diastolic dysfu...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: von Kleeck, Ryan, Roberts, Emilia, Castagnino, Paola, Bruun, Kyle, Brankovic, Sonja A, Hawthorne, Elizabeth A, Xu, Tina, Tobias, John W, Assoian, Richard K
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008950/
https://ncbi.nlm.nih.gov/pubmed/33687998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000997
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