Reduced purine biosynthesis in humans after their divergence from Neandertals

We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other primates, metabolites downstream of adenylosuccin...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Stepanova, Vita, Moczulska, Kaja Ewa, Vacano, Guido N, Kurochkin, Ilia, Ju, Xiangchun, Riesenberg, Stephan, Macak, Dominik, Maricic, Tomislav, Dombrowski, Linda, Schörnig, Maria, Anastassiadis, Konstantinos, Baker, Oliver, Naumann, Ronald, Khrameeva, Ekaterina, Vanushkina, Anna, Stekolshchikova, Elena, Egorova, Alina, Tkachev, Anna, Mazzarino, Randall, Duval, Nathan, Zubkov, Dmitri, Giavalisco, Patrick, Wilkinson, Terry G, Patterson, David, Khaitovich, Philipp, Pääbo, Svante
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Evolutionary Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133780/
https://ncbi.nlm.nih.gov/pubmed/33942714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58741
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