Reduced purine biosynthesis in humans after their divergence from Neandertals

We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other primates, metabolites downstream of adenylosuccin...

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Publicat a:eLife
Autors principals: Stepanova, Vita, Moczulska, Kaja Ewa, Vacano, Guido N, Kurochkin, Ilia, Ju, Xiangchun, Riesenberg, Stephan, Macak, Dominik, Maricic, Tomislav, Dombrowski, Linda, Schörnig, Maria, Anastassiadis, Konstantinos, Baker, Oliver, Naumann, Ronald, Khrameeva, Ekaterina, Vanushkina, Anna, Stekolshchikova, Elena, Egorova, Alina, Tkachev, Anna, Mazzarino, Randall, Duval, Nathan, Zubkov, Dmitri, Giavalisco, Patrick, Wilkinson, Terry G, Patterson, David, Khaitovich, Philipp, Pääbo, Svante
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2021
Matèries:
Evolutionary Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133780/
https://ncbi.nlm.nih.gov/pubmed/33942714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58741
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