Alternative splicing of the metalloprotease ADAMTS17 spacer regulates secretion and modulates autoproteolytic activity

ADAMTS proteases mediate biosynthesis and breakdown of secreted extracellular matrix (ECM) molecules in numerous physiological and disease processes. In addition to their catalytic domains, ADAMTS proteases contain ancillary domains, which mediate substrate recognition and ECM binding and confer dis...

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Bibliographic Details
Published in:FASEB J
Main Authors: Balic, Zerina, Misra, Saurav, Willard, Belinda, Reinhardt, Dieter P., Apte, Suneel S., Hubmacher, Dirk
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133003/
https://ncbi.nlm.nih.gov/pubmed/33484187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202001120RR
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