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An Aromatic Cluster in the Active Site of epi-Isozizaene Synthase is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways
The sesquiterpene cyclase epi-isozizaene synthase (EIZS) catalyzes the cyclization of farnesyl diphosphate to form the tricyclic precursor of the antibiotic albaflavenone. The hydrophobic active site is largely defined by aromatic residues that direct a multistep reaction sequence through multiple c...
Gardado en:
| Publicado en: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8132545/ https://ncbi.nlm.nih.gov/pubmed/33270439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00876 |
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