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Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade

The x-ray crystal structure of recombinant trichodiene synthase from Fusarium sporotrichioides has been determined to 2.5-Å resolution, both unliganded and complexed with inorganic pyrophosphate. This reaction product coordinates to three Mg(2+) ions near the mouth of the active site cleft. A compar...

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Detalhes bibliográficos
Main Authors: Rynkiewicz, Michael J., Cane, David E., Christianson, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC61077/
https://ncbi.nlm.nih.gov/pubmed/11698643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231313098
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