Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade

The x-ray crystal structure of recombinant trichodiene synthase from Fusarium sporotrichioides has been determined to 2.5-Å resolution, both unliganded and complexed with inorganic pyrophosphate. This reaction product coordinates to three Mg(2+) ions near the mouth of the active site cleft. A compar...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Rynkiewicz, Michael J., Cane, David E., Christianson, David W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC61077/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11698643/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.231313098
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