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Involvement of c-Jun N-terminal kinase 2 (JNK2) in Endothelin-1 (ET-1) Mediated Neurodegeneration of Retinal Ganglion Cells

PURPOSE: The goal of this study was to determine whether JNK2 played a causative role in endothelin-mediated loss of RGCs in mice. METHODS: JNK2(−/−) and wild type (C57BL/6) mice were intravitreally injected in one eye with 1 nmole of ET-1, whereas the contralateral eye was injected with the vehicle...

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Bibliografiske detaljer
Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Kodati, Bindu, Stankowska, Dorota L., Krishnamoorthy, Vignesh R., Krishnamoorthy, Raghu R.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131991/
https://ncbi.nlm.nih.gov/pubmed/33978676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.6.13
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