AKT/AMPK-mediated phosphorylation of TBC1D4 disrupts the interaction with insulin-regulated aminopeptidase

TBC1D4 is a 160 kDa multidomain Rab GTPase-activating protein (RabGAP) and a downstream target of the insulin- and contraction-activated kinases AKT and AMPK. Phosphorylation of TBC1D4 has been linked to translocation of GLUT4 from storage vesicles (GSVs) to the cell surface. However, its impact on...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Eickelschulte, Samaneh, Hartwig, Sonja, Leiser, Ben, Lehr, Stefan, Joschko, Viola, Chokkalingam, Manopriya, Chadt, Alexandra, Al-Hasani, Hadi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2021
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131924/
https://ncbi.nlm.nih.gov/pubmed/33872597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100637
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