Smoothened inhibition leads to decreased cell proliferation and suppressed tissue fibrosis in the development of benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH) is a common disease in aging males. It has been proven that the Hedgehog (HH) is implied as an effective and fundamental regulatory growth factor signal for organogenesis, homeostasis, and regeneration. Smoothened (SMO), as the major control point of HH signals, ac...

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Pubblicato in:Cell Death Discov
Autori principali: Liu, Jianmin, Yin, Jing, Chen, Ping, Liu, Daoquan, He, Weixiang, Li, Yan, Li, Mingzhou, Fu, Xun, Zeng, Guang, Guo, Yuming, Wang, Xinghuan, DiSanto, Michael E., Zhang, Xinhua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131753/
https://ncbi.nlm.nih.gov/pubmed/34006832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00501-4
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