Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer

Apurinic/apyrimidinic endonuclease 1 (APE1) plays a critical role in the base excision repair (BER) pathway, which is responsible for the excision of apurinic sites (AP sites). In non-small cell lung cancer (NSCLC), APE1 is highly expressed and associated with poor patient prognosis. The suppression...

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Udgivet i:Cell Death Dis
Main Authors: Long, Kaili, Gu, Lili, Li, Lulu, Zhang, Ziyu, Li, Enjie, Zhang, Yilan, He, Lingfeng, Pan, Feiyan, Guo, Zhigang, Hu, Zhigang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131371/
https://ncbi.nlm.nih.gov/pubmed/34006852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03804-7
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