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T cell-intrinsic IL6R signaling is required for optimal ICOS expression and viral control during chronic infection
The pleiotropic cytokine interleukin-6 (IL-6) plays an integral role not only in innate inflammatory responses but also in the activation and differentiation of lymphocyte subsets. Here, by using a conditional knockout model with selective IL-6 receptor deletion in T cells (IL6R-cKO), we demonstrate...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8131195/ https://ncbi.nlm.nih.gov/pubmed/31413107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801567 |
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