A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies

HIV-specific CD8(+) T cells partially control viral replication and delay disease progression, but they rarely provide lasting protection, largely due to immune escape. Here, we show that engrafting mice with memory CD4(+) T cells from HIV(+) donors uniquely allows for the in vivo evaluation of auto...

詳細記述

保存先:
書誌詳細
出版年:J Exp Med
主要な著者: McCann, Chase D., van Dorp, Christiaan H., Danesh, Ali, Ward, Adam R., Dilling, Thomas R., Mota, Talia M., Zale, Elizabeth, Stevenson, Eva M., Patel, Shabnum, Brumme, Chanson J., Dong, Winnie, Jones, Douglas S., Andresen, Thomas L., Walker, Bruce D., Brumme, Zabrina L., Bollard, Catherine M., Perelson, Alan S., Irvine, Darrell J., Jones, R. Brad
フォーマット: Artigo
言語:Inglês
出版事項: Rockefeller University Press 2021
主題:
Technical Advances and Resources
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129803/
https://ncbi.nlm.nih.gov/pubmed/33988715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201908
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