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Chromosome oscillation promotes Aurora A–dependent Hec1 phosphorylation and mitotic fidelity
Most cancer cells show chromosomal instability, a condition where chromosome missegregation occurs frequently. We found that chromosome oscillation, an iterative chromosome motion during metaphase, is attenuated in cancer cell lines. We also found that metaphase phosphorylation of Hec1 at serine 55,...
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| Publicat a: | J Cell Biol |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Rockefeller University Press
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8129796/ https://ncbi.nlm.nih.gov/pubmed/33988677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202006116 |
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