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The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity
The activity of the TRPM7 channel is negatively regulated by intracellular Mg(2+). We previously reported that oxidative stress enhances the inhibition of TRPM7 by intracellular Mg(2+). Here, we aimed to clarify the mechanism underlying TRPM7 inhibition by hydrogen peroxide (H(2)O(2)). Site-directed...
Shranjeno v:
| izdano v: | J Gen Physiol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Rockefeller University Press
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8129778/ https://ncbi.nlm.nih.gov/pubmed/33999118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012708 |
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