Local Anesthetic Lidocaine Inhibits TRPM7 Current and TRPM7‐Mediated Zinc Toxicity

BACKGROUND: Previous study demonstrated that overstimulation of TRPM7 substantially contributes to zinc‐mediated neuronal toxicity. Inhibition of TRPM7 activity and TRPM7‐mediated intracellular Zn(2+) accumulation may represent a promising strategy in the treatment of stroke. AIMS: To investigate wh...

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Publicat a:CNS Neurosci Ther
Autors principals: Leng, Tian‐Dong, Lin, Jun, Sun, Hua‐Wei, Zeng, Zhao, O'Bryant, Zaven, Inoue, Koichi, Xiong, Zhi‐Gang
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2014
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495118/
https://ncbi.nlm.nih.gov/pubmed/25169754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12318
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