Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs). Pyridoxic acid (PDA) and homovanillic acid (HVA) were indicated as potential biomarkers of OAT1/3. The objective of this study was to d...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Ahmad, Amais, Ogungbenro, Kayode, Kunze, Annett, Jacobs, Frank, Snoeys, Jan, Rostami‐Hodjegan, Amin, Galetin, Aleksandra
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129719/
https://ncbi.nlm.nih.gov/pubmed/33704919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12610
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