Comprehensive PBPK model to predict drug interaction potential of Zanubrutinib as a victim or perpetrator

A physiologically based pharmacokinetic (PBPK) model was developed to evaluate and predict (1) the effect of concomitant cytochrome P450 3A (CYP3A) inhibitors or inducers on the exposures of zanubrutinib, (2) the effect of zanubrutinib on the exposures of CYP3A4, CYP2C8, and CYP2B6 substrates, and (...

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Bibliographic Details
Published in:CPT Pharmacometrics Syst Pharmacol
Main Authors: Wang, Kun, Yao, Xueting, Zhang, Miao, Liu, Dongyang, Gao, Yuying, Sahasranaman, Srikumar, Ou, Ying C.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129716/
https://ncbi.nlm.nih.gov/pubmed/33687157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12605
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