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Comprehensive PBPK model to predict drug interaction potential of Zanubrutinib as a victim or perpetrator
A physiologically based pharmacokinetic (PBPK) model was developed to evaluate and predict (1) the effect of concomitant cytochrome P450 3A (CYP3A) inhibitors or inducers on the exposures of zanubrutinib, (2) the effect of zanubrutinib on the exposures of CYP3A4, CYP2C8, and CYP2B6 substrates, and (...
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| Publicado en: | CPT Pharmacometrics Syst Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8129716/ https://ncbi.nlm.nih.gov/pubmed/33687157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12605 |
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