Antibodies Elicited by the Shigella sonnei GMMA Vaccine in Adults Trigger Complement-Mediated Serum Bactericidal Activity: Results From a Phase 1 Dose Escalation Trial Followed by a Booster Extension

Shigella is the second most deadly diarrheal disease among children under five years of age, after rotavirus, with high morbidity and mortality in developing countries. Currently, no vaccine is widely available, and the increasing levels of multidrug resistance make Shigella a high priority for vacc...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Micoli, Francesca, Rossi, Omar, Conti, Valentino, Launay, Odile, Sciré, Antonella Silvia, Aruta, Maria Grazia, Nakakana, Usman Nasir, Marchetti, Elisa, Rappuoli, Rino, Saul, Allan, Martin, Laura B., Necchi, Francesca, Podda, Audino
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129577/
https://ncbi.nlm.nih.gov/pubmed/34017343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.671325
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