Antibodies Elicited by the Shigella sonnei GMMA Vaccine in Adults Trigger Complement-Mediated Serum Bactericidal Activity: Results From a Phase 1 Dose Escalation Trial Followed by a Booster Extension

Shigella is the second most deadly diarrheal disease among children under five years of age, after rotavirus, with high morbidity and mortality in developing countries. Currently, no vaccine is widely available, and the increasing levels of multidrug resistance make Shigella a high priority for vacc...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Micoli, Francesca, Rossi, Omar, Conti, Valentino, Launay, Odile, Sciré, Antonella Silvia, Aruta, Maria Grazia, Nakakana, Usman Nasir, Marchetti, Elisa, Rappuoli, Rino, Saul, Allan, Martin, Laura B., Necchi, Francesca, Podda, Audino
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129577/
https://ncbi.nlm.nih.gov/pubmed/34017343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.671325
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