IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques

Unlike HIV infection, which progresses to AIDS absent suppressive anti-retroviral therapy, nonpathogenic infections in natural hosts, such African green monkeys, are characterized by a lack of gut microbial translocation and robust secondary lymphoid natural killer cell responses resulting in an abs...

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izdano v:Nat Commun
Main Authors: Harper, Justin, Huot, Nicolas, Micci, Luca, Tharp, Gregory, King, Colin, Rascle, Philippe, Shenvi, Neeta, Wang, Hong, Galardi, Cristin, Upadhyay, Amit A., Villinger, Francois, Lifson, Jeffrey, Silvestri, Guido, Easley, Kirk, Jacquelin, Beatrice, Bosinger, Steven, Müller-Trutwin, Michaela, Paiardini, Mirko
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129202/
https://ncbi.nlm.nih.gov/pubmed/34001890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23189-7
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