Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules

Over the last 10 years considerable progress has been made in the application of small molecules to modulating protein-protein interactions (PPIs), and the navigation from “undruggable” to a host of candidate molecules in clinical trials has been well-charted in recent, comprehensive reviews. Struct...

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Detaylı Bibliyografya
Yayımlandı:Front Chem
Asıl Yazarlar: Lawson, Alastair D. G., MacCoss, Malcolm, Baeten, Dominique L., Macpherson, Alex, Shi, Jiye, Henry, Alistair J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2021
Konular:
Chemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129178/
https://ncbi.nlm.nih.gov/pubmed/34017820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2021.668186
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