Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets

Cryopreservation offers the potential to increase the availability of pancreatic islets for treatment of diabetic patients. However, current protocols, which use dimethyl sulfoxide (DMSO), lead to poor cryosurvival of islets. We demonstrate that equilibration of mouse islets with small molecules in...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dolezalova, Nikola, Gruszczyk, Anja, Barkan, Kerry, Gamble, John A., Galvin, Sam, Moreth, Till, O’Holleran, Kevin, Mahbubani, Krishnaa T., Higgins, Jackie A., Gribble, Fiona M., Reimann, Frank, Surmacki, Jakub, Andrews, Simon, Casey, John J., Pampaloni, Francesco, Murphy, Michael P., Ladds, Graham, Slater, Nigel K. H., Saeb-Parsy, Kourosh
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129116/
https://ncbi.nlm.nih.gov/pubmed/34001961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89853-6
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