Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets

Cryopreservation offers the potential to increase the availability of pancreatic islets for treatment of diabetic patients. However, current protocols, which use dimethyl sulfoxide (DMSO), lead to poor cryosurvival of islets. We demonstrate that equilibration of mouse islets with small molecules in...

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Vydáno v:Sci Rep
Hlavní autoři: Dolezalova, Nikola, Gruszczyk, Anja, Barkan, Kerry, Gamble, John A., Galvin, Sam, Moreth, Till, O’Holleran, Kevin, Mahbubani, Krishnaa T., Higgins, Jackie A., Gribble, Fiona M., Reimann, Frank, Surmacki, Jakub, Andrews, Simon, Casey, John J., Pampaloni, Francesco, Murphy, Michael P., Ladds, Graham, Slater, Nigel K. H., Saeb-Parsy, Kourosh
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129116/
https://ncbi.nlm.nih.gov/pubmed/34001961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89853-6
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