Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-Mediated ARDS

OBJECTIVES: Identify the metabolites that are increased in the plasma of severely injured patients that developed ARDS versus severely injured patients that did not, and assay if these increased metabolites prime PMNs and induce pulmonary sequestration in an animal model of ARDS. We hypothesize that...

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Publicat a:Ann Surg
Autors principals: Nunns, Geoffrey R, Vigneshwar, Navin, Kelher, Marguerite R, Stettler, Gregory R, Gera, Lajos, Reisz, Julie A., D’Alessandro, Angelo, Ryon, Joshua, Hansen, Kirk C, Burke, Timothy, Gamboni, Fabia, Moore, Ernest E., Peltz, Erik D, Cohen, Mitchell J, Jones, Kenneth L, Sauaia, Angela, Liang, Xiayuan, Banerjee, Anirban, Ghasabyan, Arsen, Chandler, James G, Rodawig, Sophia, Jones, Carter, Eitel, Andrew, Hom, Patrick, Silliman, Christopher C
Format: Artigo
Idioma:Inglês
Publicat: 2022
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8128932/
https://ncbi.nlm.nih.gov/pubmed/33214479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SLA.0000000000004644
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