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Generation of reactive oxygen species is the primary mode of action and cause of survivin suppression by sepantronium bromide (YM155)
Survivin is a lucrative broad-spectrum drug target for different cancer types, including triple negative breast cancer (TNBC). Sepantronium bromide (YM155) is the first of its class of survivin suppressants and was found to be quite effective in pre-clinical models of TNBC. However, in clinical tria...
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| Publicado no: | RSC Med Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
RSC
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8128069/ https://ncbi.nlm.nih.gov/pubmed/34046628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00383b |
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