Mutant Nmnat1 leads to a retina-specific decrease of NAD(+) accompanied by increased poly(ADP-ribose) in a mouse model of NMNAT1-associated retinal degeneration

Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) is required for nuclear nicotinamide adenine mononucleotide (NAD(+)) biosynthesis in all nucleated cells, and despite its functional ubiquity, mutations in this gene lead to an isolated retinal degeneration. The mechanisms underlying how mut...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Greenwald, Scott H, Brown, Emily E, Scandura, Michael J, Hennessey, Erin, Farmer, Raymond, Du, Jianhai, Wang, Yekai, Pierce, Eric A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
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General Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127407/
https://ncbi.nlm.nih.gov/pubmed/33709122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddab070
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