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The bZIP mutant CEBPB (V285A) has sequence specific DNA binding propensities similar to CREB1
The bZIP homodimers CEBPB and CREB1 bind DNA containing methylated cytosines differently. CREB1 binds stronger to the C/EBP half-site GCAA when the cytosine is methylated. For CEBPB, methylation of the same cytosine does not affect DNA binding. The X-ray structure of CREB1 binding the half site GTCA...
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| Veröffentlicht in: | Biochim Biophys Acta Gene Regul Mech |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8127354/ https://ncbi.nlm.nih.gov/pubmed/30825655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2019.02.002 |
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