The bZIP mutant CEBPB (V285A) has sequence specific DNA binding propensities similar to CREB1

The bZIP homodimers CEBPB and CREB1 bind DNA containing methylated cytosines differently. CREB1 binds stronger to the C/EBP half-site GCAA when the cytosine is methylated. For CEBPB, methylation of the same cytosine does not affect DNA binding. The X-ray structure of CREB1 binding the half site GTCA...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta Gene Regul Mech
Main Authors: Ray, Sreejana, Ufot, Aniekanabasi, Assad, Nima, Singh, Jocelyn, Durell, Stewart R., Porollo, Aleksey, Tillo, Desiree, Vinson, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127354/
https://ncbi.nlm.nih.gov/pubmed/30825655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2019.02.002
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