Replacing C189 in the bZIP domain of Zta with S, T, V, or A changes DNA binding specificity to four types of double stranded DNA

Zta is a bZIP transcription factor (TF) in the Epstein-Barr virus that binds unmethylated and methylated DNA sequences. Substitution of cysteine 189 of Zta to serine (Zta(C189S)) results in a virus that is unable to execute the lytic cycle which was attributed to a change in binding to methylated DN...

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Vydáno v:Biochem Biophys Res Commun
Hlavní autoři: Ray, Sreejana, Tillo, Desiree, Assad, Nima, Ufot, Aniekanabasi, Deppmann, Christopher, Durell, Stewart R., Porollo, Aleksey, Vinson, Charles
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417095/
https://ncbi.nlm.nih.gov/pubmed/29772230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.05.080
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