Llwytho...
Replacing C189 in the bZIP domain of Zta with S, T, V, or A changes DNA binding specificity to four types of double stranded DNA
Zta is a bZIP transcription factor (TF) in the Epstein-Barr virus that binds unmethylated and methylated DNA sequences. Substitution of cysteine 189 of Zta to serine (Zta(C189S)) results in a virus that is unable to execute the lytic cycle which was attributed to a change in binding to methylated DN...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Biochem Biophys Res Commun |
|---|---|
| Prif Awduron: | , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6417095/ https://ncbi.nlm.nih.gov/pubmed/29772230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.05.080 |
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