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Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer

Many clinical trials are being conducted to clarify effective combinations of various drugs for immune checkpoint blockade (ICB) therapy. However, although extensive studies from multiple aspects have been conducted regarding treatments for pancreatic ductal adenocarcinoma (PDAC), there are still no...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Hashimoto, Ari, Handa, Haruka, Hata, Soichiro, Tsutaho, Akio, Yoshida, Takao, Hirano, Satoshi, Hashimoto, Shigeru, Sabe, Hisataka
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127265/
https://ncbi.nlm.nih.gov/pubmed/34001163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-021-00733-y
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