Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

We lack a mechanistic understanding of aging-mediated changes in mitochondrial bioenergetics and lipid metabolism that affect T cell function. The bioactive sphingolipid ceramide, induced by aging stress, mediates mitophagy and cell death; however, the aging-related roles of ceramide metabolism in r...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Vaena, Silvia, Chakraborty, Paramita, Lee, Han Gyul, Janneh, Alhaji H., Kassir, Mohamed Faisal, Beeson, Gyda, Hedley, Zachariah, Yalcinkaya, Ahmet, Sofi, M. Hanief, Li, Hong, Husby, Monica L., Stahelin, Robert V., Yu, Xue-Zhong, Mehrotra, Shikhar, Ogretmen, Besim
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127241/
https://ncbi.nlm.nih.gov/pubmed/33951438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109076
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