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Mannosylated Cationic Copolymers for Gene Delivery to Macrophages

Macrophages are desirable targets for gene therapy of cancer and other diseases. Cationic diblock copolymers of polyethylene glycol (PEG) and poly-L-lysine (PLL) or poly{N-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (pAsp(DET)) are synthesized and used to form polyplexes with a plasmid DNA (pDNA) th...

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Dades bibliogràfiques
Publicat a:Macromol Biosci
Autors principals: Lopukhov, Anton V., Yang, Zigang, Haney, Matthew J., Bronich, Tatiana K., Sokolsky-Papkov, Marina, Batrakova, Elena V., Klyachko, Natalia L., Kabanov, Alexander V.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126558/
https://ncbi.nlm.nih.gov/pubmed/33615675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mabi.202000371
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