Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding

Activation of T cells by agonistic peptide-MHC can be inhibited by antagonistic ones. However, the exact mechanism remains elusive. We used Jurkat cells expressing two different TCRs and tested whether stimulation of the endogenous TCR by agonistic anti-Vβ8 antibodies can be modulated by ligand-bind...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Yousefi, Omid Sascha, Ruggieri, Matias, Idstein, Vincent, von Prillwitz, Kai Uwe, Herr, Laurenz A., Chalupsky, Julia, Köhn, Maja, Weber, Wilfried, Timmer, Jens, Schamel, Wolfgang W. A.
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8124730/
https://ncbi.nlm.nih.gov/pubmed/34066527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094920
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