Development of Exhaustion and Acquisition of Regulatory Function by Infiltrating CD8+CD28− T Lymphocytes Dictate Clinical Outcome in Head and Neck Cancer

SIMPLE SUMMARY: CD8+ T lymphocytes are among the immune cells reputed to kill tumor cells. Head and neck squamous cell carcinoma (HNSCC) has a poor clinical outcome despite the presence of a rich CD8+ T cell tumor infiltrate. This may be due to alterations of tumor infiltrating CD8+ T cells. Here, w...

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Publicat a:Cancers (Basel)
Autors principals: Fenoglio, Daniela, Belgioia, Liliana, Parodi, Alessia, Missale, Francesco, Bacigalupo, Almalina, Tarke, Alison, Incandela, Fabiola, Negrini, Simone, Vecchio, Stefania, Altosole, Tiziana, Vlah, Sara, Astone, Giuseppina, Costabile, Francesca, Ascoli, Alessandro, Ferrera, Francesca, Schenone, Guido, De Palma, Raffaele, Signori, Alessio, Peretti, Giorgio, Corvò, Renzo, Filaci, Gilberto
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8124419/
https://ncbi.nlm.nih.gov/pubmed/34066538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13092234
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