An early-stage 3D fibroblast-featured tumor model mimics the gene expression of the naïve tumor microenvironment, including genes involved in cancer progression and drug resistance

IntroductionThe tumor microenvironment (TME) plays a crucial role in cancer progression, yet the interactions between tumor cells and stromal components, such as fibroblasts, remain poorly understood. Traditional two-dimensional (2D) culture models fail to accurately replicate the complexities of th...

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Detalhes bibliográficos

Principais autores:	Francesca Costabile, Subin George, Andrea Facciabene, Gilberto Filaci, Maddalena Mastrogiacomo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-10-01
coleção:	Frontiers in Oncology
Assuntos:	B16F0 melanoma cell fibroblasts NIH3T3 tumor microenvironment (TME) gene signature spheroid model
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1572315/full
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