An early-stage 3D fibroblast-featured tumor model mimics the gene expression of the naïve tumor microenvironment, including genes involved in cancer progression and drug resistance

IntroductionThe tumor microenvironment (TME) plays a crucial role in cancer progression, yet the interactions between tumor cells and stromal components, such as fibroblasts, remain poorly understood. Traditional two-dimensional (2D) culture models fail to accurately replicate the complexities of th...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Francesca Costabile, Subin George, Andrea Facciabene, Gilberto Filaci, Maddalena Mastrogiacomo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-10-01
Edice:	Frontiers in Oncology
Témata:	B16F0 melanoma cell fibroblasts NIH3T3 tumor microenvironment (TME) gene signature spheroid model
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1572315/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!