Development of an Acid-Labile Ketal Linked Amphiphilic Block Copolymer Nanoparticles for pH-Triggered Release of Paclitaxel

Here, we report on the construction of biodegradable poly(ethylene oxide monomethyl ether) (MPEO)-b-poly(ε-caprolactone) (PCL) nanoparticles (NPs) having acid-labile (acyclic ketal group) linkage at the block junction. In the presence of acidic pH, the nanoassemblies were destabilized as a consequen...

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Bibliographic Details
Published in:Polymers (Basel)
Main Authors: Petrova, Svetlana Lukáš, Jäger, Eliézer, Jäger, Alessandro, Höcherl, Anita, Konefał, Rafał, Zhigunov, Alexander, Pavlova, Ewa, Janoušková, Olga, Hrubý, Martin
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8124141/
https://ncbi.nlm.nih.gov/pubmed/34062772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/polym13091465
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