Sputum cell‐free DNA: Valued surrogate sample for the detection of EGFR exon 20 p.T790M mutation in patients with advanced lung adenocarcinoma and acquired resistance to EGFR‐TKIs

BACKGROUND: Sputum cell‐free DNA (cfDNA) is a valuable surrogate sample for assessing EGFR‐sensitizing mutations in patients with advanced lung adenocarcinoma. Detecting EGFR exon 20 p.T790 M (p.T790 M) is much more challenging due to its limited availability in tumor tissues. Exploring sputum cfDNA...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Wang, Zheng, Li, Xiaoguang, Zhang, Lin, Xu, Yan, Wang, Mengzhao, Liang, Li, Jiao, Peng, Li, Yuanming, He, Shurong, Du, Jun, He, Lei, Tang, Min, Sun, Mingjun, Yang, Li, Di, Jing, Zhu, Guanshan, Li, Lin, Liu, Dongge
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8124129/
https://ncbi.nlm.nih.gov/pubmed/33932095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3817
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