Contribution of KRAS mutations and c.2369C > T (p.T790M) EGFR to acquired resistance to EGFR-TKIs in EGFR mutant NSCLC: a study on circulating tumor DNA

INTRODUCTION: KRAS oncogene mutations ((MUT)KRAS) drive resistance to EGFR inhibition by providing alternative signaling as demonstrated in colo-rectal cancer. In non-small cell lung cancer (NSCLC), the efficacy of treatment with EGFR tyrosine kinase inhibitors (EGFR-TKIs) depends on activating EGFR...

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Publicat a:Oncotarget
Autors principals: Del Re, Marzia, Tiseo, Marcello, Bordi, Paola, D'Incecco, Armida, Camerini, Andrea, Petrini, Iacopo, Lucchesi, Maurizio, Inno, Alessandro, Spada, Daniele, Vasile, Enrico, Citi, Valentina, Malpeli, Giorgio, Testa, Enrica, Gori, Stefania, Falcone, Alfredo, Amoroso, Domenico, Chella, Antonio, Cappuzzo, Federico, Ardizzoni, Andrea, Scarpa, Aldo, Danesi, Romano
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355124/
https://ncbi.nlm.nih.gov/pubmed/26799287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6957
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