Precision targeting of the plasminogen activator inhibitor‐1 mechanism increases efficacy of fibrinolytic therapy in empyema

Plasminogen activator inhibitor‐1 (PAI‐1) is an endogenous irreversible inhibitor of tissue‐type (tPA) and urokinase (uPA) plasminogen activators. PAI‐1‐targeted fibrinolytic therapy (PAI‐1‐TFT) is designed to decrease the therapeutic dose of tPA and uPA, attenuating the risk of bleeding and other c...

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Опубликовано в: :Physiol Rep
Главные авторы: Florova, Galina, Girard, René A., Azghani, Ali O., Sarva, Krishna, Buchanan, Ann, Karandashova, Sophia, DeVera, Christian J., Morris, Danna, Chamiso, Mignote, Koenig, Kathleen, Cines, Douglas B., Idell, Steven, Komissarov, Andrey A.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2021
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8123555/
https://ncbi.nlm.nih.gov/pubmed/33991465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14861
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