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Precision targeting of the plasminogen activator inhibitor‐1 mechanism increases efficacy of fibrinolytic therapy in empyema

Plasminogen activator inhibitor‐1 (PAI‐1) is an endogenous irreversible inhibitor of tissue‐type (tPA) and urokinase (uPA) plasminogen activators. PAI‐1‐targeted fibrinolytic therapy (PAI‐1‐TFT) is designed to decrease the therapeutic dose of tPA and uPA, attenuating the risk of bleeding and other c...

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Библиографические подробности
Опубликовано в: :Physiol Rep
Главные авторы: Florova, Galina, Girard, René A., Azghani, Ali O., Sarva, Krishna, Buchanan, Ann, Karandashova, Sophia, DeVera, Christian J., Morris, Danna, Chamiso, Mignote, Koenig, Kathleen, Cines, Douglas B., Idell, Steven, Komissarov, Andrey A.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2021
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8123555/
https://ncbi.nlm.nih.gov/pubmed/33991465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14861
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