Targeting of Plasminogen Activator Inhibitor 1 Improves Fibrinolytic Therapy for Tetracycline-Induced Pleural Injury in Rabbits

Endogenous active plasminogen activator inhibitor 1 (PAI-1) was targeted in vivo with monoclonal antibodies (mAbs) that redirect its reaction with proteinases to the substrate branch. mAbs were used as an adjunct to prourokinase (single-chain [sc] urokinase [uPA]) intrapleural fibrinolytic therapy (...

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Zapisane w:
Opis bibliograficzny
Wydane w:Am J Respir Cell Mol Biol
Główni autorzy: Florova, Galina, Azghani, Ali, Karandashova, Sophia, Schaefer, Chris, Koenig, Kathleen, Stewart-Evans, Kris, Declerck, Paul J., Idell, Steven, Komissarov, Andrey A.
Format: Artigo
Język:Inglês
Wydane: American Thoracic Society 2015
Hasła przedmiotowe:
Original Research
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491122/
https://ncbi.nlm.nih.gov/pubmed/25140386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0168OC
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