Kynurenine/Tryptophan Ratio as a Potential Blood-Based Biomarker in Non-Small Cell Lung Cancer

The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) degrade tryptophan (Trp) into kynurenine (Kyn) at the initial step of an enzymatic pathway affecting T cell proliferation. IDO1 is highly expressed in various cancer types and associated with poor prognosis. Nevertheless, the serum Kyn/Trp concentratio...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Mandarano, Martina, Orecchini, Elena, Bellezza, Guido, Vannucci, Jacopo, Ludovini, Vienna, Baglivo, Sara, Tofanetti, Francesca Romana, Chiari, Rita, Loreti, Elisabetta, Puma, Francesco, Sidoni, Angelo, Belladonna, Maria Laura
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8122814/
https://ncbi.nlm.nih.gov/pubmed/33922388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094403
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