A Reversible Shift of Driver Dependence from EGFR to Notch1 in Non-Small Cell Lung Cancer as a Cause of Resistance to Tyrosine Kinase Inhibitors

SIMPLE SUMMARY: Notch1 and EGFR are two surface receptors activating different cellular processes in cancer cells. EGFR, harboring activating mutations, drives unlimited cell proliferation in non-small cell lung cancer (NSCLC), and treatment of tumors with tyrosine kinase inhibitors (TKIs) results i...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Iommelli, Francesca, De Rosa, Viviana, Terlizzi, Cristina, Fonti, Rosa, Camerlingo, Rosa, Stoppelli, Maria Patrizia, Stewart, C. Allison, Byers, Lauren Averett, Piwnica-Worms, David, Del Vecchio, Silvana
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8122511/
https://ncbi.nlm.nih.gov/pubmed/33922104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13092022
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