Early (18)F-FDG uptake as a reliable imaging biomarker of T790M-mediated resistance but not MET amplification in non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

BACKGROUND: The two main mechanisms of resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) are the occurrence of T790M secondary mutation in the kinase domain of EGFR and MET amplification. The aim of the present study was to test whether early changes of (18)F...

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Detalles Bibliográficos
Publicado en:EJNMMI Res
Autores principales: De Rosa, Viviana, Iommelli, Francesca, Monti, Marcello, Mainolfi, Ciro Gabriele, Fonti, Rosa, Del Vecchio, Silvana
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056924/
https://ncbi.nlm.nih.gov/pubmed/27726115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-016-0229-0
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