Early (18)F-FDG uptake as a reliable imaging biomarker of T790M-mediated resistance but not MET amplification in non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

BACKGROUND: The two main mechanisms of resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) are the occurrence of T790M secondary mutation in the kinase domain of EGFR and MET amplification. The aim of the present study was to test whether early changes of (18)F...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: De Rosa, Viviana, Iommelli, Francesca, Monti, Marcello, Mainolfi, Ciro Gabriele, Fonti, Rosa, Del Vecchio, Silvana
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056924/
https://ncbi.nlm.nih.gov/pubmed/27726115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-016-0229-0
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