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Comparison of gene expression and biotransformation activity of HepaRG cells under static and dynamic culture conditions
Flow conditions have been shown to be important in improving longevity and functionality of primary hepatocytes, but the impact of flow on HepaRG cells is largely unknown. We studied the expression of genes encoding CYP enzymes and transporter proteins and CYP1 and CYP3A4 activity during 8 weeks of...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8121841/ https://ncbi.nlm.nih.gov/pubmed/33990636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89710-6 |
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