Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia

Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role in BC, the landscape and prognostic impact of these alterations remain elusive. Here, we comprehensively investigate genetic abnormalities in 136 B...

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Publicado no:Nat Commun
Main Authors: Ochi, Yotaro, Yoshida, Kenichi, Huang, Ying-Jung, Kuo, Ming-Chung, Nannya, Yasuhito, Sasaki, Ko, Mitani, Kinuko, Hosoya, Noriko, Hiramoto, Nobuhiro, Ishikawa, Takayuki, Branford, Susan, Shanmuganathan, Naranie, Ohyashiki, Kazuma, Takahashi, Naoto, Takaku, Tomoiku, Tsuchiya, Shun, Kanemura, Nobuhiro, Nakamura, Nobuhiko, Ueda, Yasunori, Yoshihara, Satoshi, Bera, Rabindranath, Shiozawa, Yusuke, Zhao, Lanying, Takeda, June, Watatani, Yosaku, Okuda, Rurika, Makishima, Hideki, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Sanada, Masashi, Takaori-Kondo, Akifumi, Miyano, Satoru, Ogawa, Seishi, Shih, Lee-Yung
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121838/
https://ncbi.nlm.nih.gov/pubmed/33990592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23097-w
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