Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase

Government-sanctioned use of nerve agents (NA) has escalated dramatically in recent years. Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serve as antidotes toward poisoning by OPNAs. The oximes used as therapeutics are quaternary co...

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Détails bibliographiques
Publié dans:Commun Biol
Auteurs principaux: Amitai, Gabriel, Plotnikov, Alexander, Chapman, Shira, Lazar, Shlomi, Gez, Rellie, Loewenthal, Dan, Shurrush, Khriesto A., Cohen, Galit, Solmesky, Leonardo J., Barr, Haim, Russell, Alan J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121814/
https://ncbi.nlm.nih.gov/pubmed/33990679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02061-w
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