Tissue-resident-like CD4(+) T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung

T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung, and is generally studied in humans using peripheral blood cells. Mounting evidence, however, indicates that tissue-resident memory T cells (Trms) are superior at controlling many pathogens, including...

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Pubblicato in:J Clin Invest
Autori principali: Ogongo, Paul, Tezera, Liku B., Ardain, Amanda, Nhamoyebonde, Shepherd, Ramsuran, Duran, Singh, Alveera, Ng’oepe, Abigail, Karim, Farina, Naidoo, Taryn, Khan, Khadija, Dullabh, Kaylesh J., Fehlings, Michael, Lee, Boon Heng, Nardin, Alessandra, Lindestam Arlehamn, Cecilia S., Sette, Alessandro, Behar, Samuel M., Steyn, Adrie J.C., Madansein, Rajhmun, Kløverpris, Henrik N., Elkington, Paul T., Leslie, Alasdair
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121523/
https://ncbi.nlm.nih.gov/pubmed/33848273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI142014
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